GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs2275426 | 1 | rs10890363 | chr1:46356148 | CCDC163P | chr1:45960581-45965646:- | 0.49 | 6 | 3.55E-8 | Body mass index |
| THYM | cis | rs2275426 | 1 | rs10890383 | chr1:46588503 | CCDC163P | chr1:45960581-45965646:- | -0.46 | -5.33 | 6.71E-7 | Body mass index |
| THYM | cis | rs494003 | 1 | rs10896043 | chr11:65543827 | SNX32 | chr11:65601410-65621170:+ | -0.41 | -4.48 | 2.05E-5 | Systemic lupus erythematosus |
| THYM | cis | rs2077224 | 1 | rs10897274 | chr11:62200369 | ASRGL1 | chr11:62104774-62160885:+ | 0.31 | 4.44 | 2.45E-5 | Chronic obstructive pulmonary disease-related biomarkers |
| THYM | cis | rs7072122 | 1 | rs10900062 | chr10:45039599 | ZNF22 | chr10:45496273-45500776:+ | 0.47 | 4.63 | 1.16E-5 | Estradiol plasma levels (breast cancer) |
| THYM | cis | rs7072122 | 1 | rs10900063 | chr10:45045250 | ZNF22 | chr10:45496273-45500776:+ | 0.58 | 5.21 | 1.1E-6 | Estradiol plasma levels (breast cancer) |
| THYM | cis | rs7072122 | 1 | rs10900064 | chr10:45057471 | ZNF22 | chr10:45496273-45500776:+ | 0.57 | 5.19 | 1.21E-6 | Estradiol plasma levels (breast cancer) |
| THYM | cis | rs6598955 | 1 | rs10902728 | chr1:26598281 | CD52 | chr1:26644411-26647013:+ | 0.21 | 4.28 | 4.51E-5 | Obesity-related traits |
| THYM | cis | rs6684514 | 1 | rs10908498 | chr1:156278175 | CCT3 | chr1:156278752-156308195:- | -0.18 | -4.17 | 6.84E-5 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| THYM | cis | rs6684514 | 1 | rs10908499 | chr1:156279176 | CCT3 | chr1:156278752-156308195:- | -0.18 | -4.17 | 6.84E-5 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| THYM | cis | rs6684514 | 1 | rs10908500 | chr1:156280671 | CCT3 | chr1:156278752-156308195:- | -0.18 | -4.17 | 6.84E-5 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| THYM | cis | rs6696239 | 1 | rs10916199 | chr1:227902472 | DUSP5P | chr1:228780657-228788159:+ | -0.61 | -4.7 | 8.8E-6 | Height |
| THYM | cis | rs10935120 | 1 | rs10935120 | chr3:134233092 | ANAPC13 | chr3:134196547-134204865:- | -0.56 | -7.61 | 1.94E-11 | Height |
| THYM | cis | rs10935120 | 1 | rs10935120 | chr3:134233092 | CEP63 | chr3:134204575-134293852:+ | -0.41 | -6 | 3.54E-8 | Height |
| THYM | cis | rs1401999 | 1 | rs10937158 | chr3:183708439 | ABCC5 | chr3:183637726-183735727:- | 0.48 | 4.28 | 4.53E-5 | Anterior chamber depth |